![]() Elevated cGMP stimulates secretion of chloride and bicarbonate and water into the intestinal lumen, mainly by way of cystic fibrosis transmembrane conductance regulator (CFTR) ion channel activation. Activation of GC-C increases cyclic guanosine monophosphate (cGMP). Linaclotide is minimally absorbed and it is undetectable in the systemic circulation at therapeutic doses. The medication binds to the surface of the intestinal epithelial cells. Linaclotide, like the endogenous guanylin and uroguanylin it mimics, is an agonist that activates the cell surface receptor of guanylate cyclase 2C (GC-C). Systemic absorption of the globular tetradecapeptide is minimal. Between 1% and 10% of people have decreased appetite, dehydration, low potassium, dizziness when standing up too quickly, nausea, vomiting, urgent need to defecate, fecal incontinence, and bleeding in the colon, rectum, and anus. More than 10% of people taking linaclotide have diarrhea. The US label has a black box warning to not use linaclotide in children less than 6 years old and to avoid in people from 6 to 18 years old, due to the risk of serious dehydration. It has not been tested in pregnant women and it is unknown if it is excreted in breast milk. Rest assured, we only affiliate with our authorized dispensaries that procure products through reliable sources.Linaclotide is used to treat irritable bowel syndrome with constipation and chronic constipation with no known cause. The products are sourced from various countries as well as those listed above. The items in your order may be shipped from any of the above jurisdictions. We affiliate with other dispensaries that ship products to our customers from the following jurisdictions: Canada, Singapore, New Zealand, Turkey, Mauritius, India, and the United Kingdom. Please note that not all products, including any referenced on this page, are shipped by our affiliated Canadian Pharmacy. If you require any advice or information about the drugs on this page, a medical condition or treatment advice, you should always speak to a health professional. BigMountainDrugs relies on these third parties to create and maintain this information and cannot guarantee the medical efficacy, accuracy or reliability of the information that has been provided to us. If you have any questions about placing your order, contact us at our toll-free service at 1.877.223.9977 or email content on this page has been supplied to by an independent third party contracted to provide information for our website. Linzess works by elevating certain chemicals in the intestines that increase the secretion or chloride and bicarbonate, which in turn increases intestinal fluid and accelerates transit through the digestive system. Linzess may improve stool texture and lessen symptoms such as bloating, abdominal pain/discomfort, straining, and feelings of incomplete bowel movements. We are supplying in a quantity of 90 capsules.Ĭonstella (Linaclotide) is used to treat chronic idiopathic constipation (CIC), or chronic irritable bowl syndrome with constipation as the main symptom (IBS-C). currently stocks brand name Linzess 145 mcg also known as Constella from Canada manufactured by Allergan. ![]()
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